Vitamin D Status as a Determinant of Peak Bone Mass in Young Finnish Men

Eventos Médicos

Vitamin D Status as a Determinant of Peak Bone Mass in Young Finnish Men

por site em 15 de abril de 2021


V. V. Välimäki*1, H. Alfthan*2, E. Löyttyniemi*3, H. Suominen*4, M. J. Välimäki*1. 1Division of Endocrinology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland, 2Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland, 3Department of Statistics, University of Turku, Turku, Finland, 4Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.

Severe vitamin D deficiency causes rickets, but scarce data is available on to what extent a milder hypovitaminosis D determines the development of the peak bone mass in young adults. Our aim was to evaluate the prevalence of hypovitaminosis D {serum 25-hydroxyvitamin D [25(OH)D] ? 37.5 nmol/l} and the relationship between vitamin D status and peak bone mass among young Finnish men.
A cross-sectional study of determinants of peak bone mass with data on lifestyle factors collected retrospectively was performed in 220 young men, aged 18.3 to 20.6 years. 170 men were recruits of the Finnish Army, and 50 were men of similar age, who had postponed their military service for reasons not related to health. Bone mineral density (BMD) was measured in lumbar spine and upper femur by dual-energy X-ray absorptiometry (DXA). Serum 25(OH)D concentrations were followed prospectively for one year.
In July 2000 26.8% of the men had hypovitaminosis D. Six months later in wintertime the respective percentage was 94.6% and next summer 29.8%. After adjusting for age, height, weight, exercise, smoking, calcium and alcohol intake there existed a positive correlation between serum 25(OH)D and lumbar spine (p=0.035), femoral neck (p=0.061), trochanter (p=0.056), and total hip (p=0.068) BMD. Of the two determinants of areal BMD, bone mineral content (BMC) but not scan area correlated with vitamin D status.
Hypovitaminosis D is very common in Finnish young men, especially during wintertime, and it may have detrimental effects on the acquisition of maximal peak bone mass. Since in Finland vitamin D supplementation to infants is now stopped at the age of three years, it can be asked, whether it at our latitude should be continued from that age onwards, no more for the prevention of rickets but as a prophylaxis of osteoporosis.